Inherited variation in circadian rhythm genes and risks of prostate cancer and three other cancer sites in combined cancer consortia.
Identifieur interne : 000979 ( Main/Exploration ); précédent : 000978; suivant : 000980Inherited variation in circadian rhythm genes and risks of prostate cancer and three other cancer sites in combined cancer consortia.
Auteurs : Fangyi Gu [États-Unis] ; Han Zhang [États-Unis] ; Paula L. Hyland [États-Unis] ; Sonja Berndt [États-Unis] ; Susan M. Gapstur [États-Unis] ; William Wheeler [États-Unis] ; The Ellipse Consortium ; Christopher I. Amos [États-Unis] ; Stephane Bezieau [France] ; Heike Bickeböller [Allemagne] ; Hermann Brenner [Allemagne] ; Paul Brennan [France] ; Jenny Chang-Claude [Allemagne] ; David V. Conti [États-Unis] ; Jennifer Anne Doherty [États-Unis] ; Stephen B. Gruber [États-Unis] ; Tabitha A. Harrison [États-Unis] ; Richard B. Hayes [États-Unis] ; Michael Hoffmeister [Allemagne] ; Richard S. Houlston [Royaume-Uni] ; Rayjean J. Hung [Canada] ; Mark A. Jenkins [Australie] ; Peter Kraft [États-Unis] ; Kate Lawrenson [États-Unis] ; James Mckay [France] ; Sarah Markt [États-Unis] ; Lorelei Mucci [États-Unis] ; Catherine M. Phelan [États-Unis] ; Conghui Qu [États-Unis] ; Angela Risch [Autriche] ; Mary Anne Rossing [États-Unis] ; H-Erich Wichmann [Allemagne] ; Jianxin Shi [États-Unis] ; Eva Schernhammer [États-Unis] ; Kai Yu [États-Unis] ; Maria Teresa Landi [États-Unis] ; Neil E. Caporaso [États-Unis]Source :
- International journal of cancer [ 1097-0215 ] ; 2017.
Descripteurs français
- KwdFr :
- Arylalkylamine N-Acetyltransferase (génétique), Carcinogenèse (génétique), Facteurs de transcription à motif basique hélice-boucle-hélice (génétique), Femelle, Humains, Mâle, Polymorphisme de nucléotide simple, Protéines de tissu nerveux (génétique), Prédisposition génétique à une maladie, Rythme circadien (génétique), Transduction du signal (génétique), Tumeurs colorectales (anatomopathologie), Tumeurs colorectales (génétique), Tumeurs de l'ovaire (anatomopathologie), Tumeurs de l'ovaire (génétique), Tumeurs de la prostate (anatomopathologie), Tumeurs de la prostate (génétique), Tumeurs du poumon (anatomopathologie), Tumeurs du poumon (génétique), Études d'associations génétiques.
- MESH :
- anatomopathologie : Tumeurs colorectales, Tumeurs de l'ovaire, Tumeurs de la prostate, Tumeurs du poumon.
- génétique : Arylalkylamine N-Acetyltransferase, Carcinogenèse, Facteurs de transcription à motif basique hélice-boucle-hélice, Protéines de tissu nerveux, Rythme circadien, Transduction du signal, Tumeurs colorectales, Tumeurs de l'ovaire, Tumeurs de la prostate, Tumeurs du poumon.
- Femelle, Humains, Mâle, Polymorphisme de nucléotide simple, Prédisposition génétique à une maladie, Études d'associations génétiques.
English descriptors
- KwdEn :
- Arylalkylamine N-Acetyltransferase (genetics), Basic Helix-Loop-Helix Transcription Factors (genetics), Carcinogenesis (genetics), Circadian Rhythm (genetics), Colorectal Neoplasms (genetics), Colorectal Neoplasms (pathology), Female, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Lung Neoplasms (genetics), Lung Neoplasms (pathology), Male, Nerve Tissue Proteins (genetics), Ovarian Neoplasms (genetics), Ovarian Neoplasms (pathology), Polymorphism, Single Nucleotide, Prostatic Neoplasms (genetics), Prostatic Neoplasms (pathology), Signal Transduction (genetics).
- MESH :
- chemical , genetics : Arylalkylamine N-Acetyltransferase, Basic Helix-Loop-Helix Transcription Factors, Nerve Tissue Proteins.
- genetics : Carcinogenesis, Circadian Rhythm, Colorectal Neoplasms, Lung Neoplasms, Ovarian Neoplasms, Prostatic Neoplasms, Signal Transduction.
- pathology : Colorectal Neoplasms, Lung Neoplasms, Ovarian Neoplasms, Prostatic Neoplasms.
- Female, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Male, Polymorphism, Single Nucleotide.
Abstract
Circadian disruption has been linked to carcinogenesis in animal models, but the evidence in humans is inconclusive. Genetic variation in circadian rhythm genes provides a tool to investigate such associations. We examined associations of genetic variation in nine core circadian rhythm genes and six melatonin pathway genes with risk of colorectal, lung, ovarian and prostate cancers using data from the Genetic Associations and Mechanisms in Oncology (GAME-ON) network. The major results for prostate cancer were replicated in the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial, and for colorectal cancer in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO). The total number of cancer cases and controls was 15,838/18,159 for colorectal, 14,818/14,227 for prostate, 12,537/17,285 for lung and 4,369/9,123 for ovary. For each cancer site, we conducted gene-based and pathway-based analyses by applying the summary-based Adaptive Rank Truncated Product method (sARTP) on the summary association statistics for each SNP within the candidate gene regions. Aggregate genetic variation in circadian rhythm and melatonin pathways were significantly associated with the risk of prostate cancer in data combining GAME-ON and PLCO, after Bonferroni correction (ppathway < 0.00625). The two most significant genes were NPAS2 (pgene = 0.0062) and AANAT (pgene = 0.00078); the latter being significant after Bonferroni correction. For colorectal cancer, we observed a suggestive association with the circadian rhythm pathway in GAME-ON (ppathway = 0.021); this association was not confirmed in GECCO (ppathway = 0.76) or the combined data (ppathway = 0.17). No significant association was observed for ovarian and lung cancer. These findings support a potential role for circadian rhythm and melatonin pathways in prostate carcinogenesis. Further functional studies are needed to better understand the underlying biologic mechanisms.
DOI: 10.1002/ijc.30883
PubMed: 28699174
Affiliations:
- Allemagne, Australie, Autriche, Canada, France, Royaume-Uni, États-Unis
- Auvergne-Rhône-Alpes, Bade-Wurtemberg, Basse-Saxe, Bavière, Californie, District de Haute-Bavière, District de Karlsruhe, Floride, Géorgie (États-Unis), Maryland, Massachusetts, New Hampshire, Pays de la Loire, Rhône-Alpes, Utah, Victoria (État), Washington (État), État de New York
- Göttingen, Heidelberg, Lyon, Melbourne, Munich, Nantes
- Université Louis-et-Maximilien de Munich, Université de Melbourne
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Le document en format XML
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Hayes</name><affiliation wicri:level="2"><nlm:affiliation>Department of Population Health, New York University School of Medicine, New York, NY.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Population Health, New York University School of Medicine, New York</wicri:cityArea></affiliation></author><author><name sortKey="Hoffmeister, Michael" sort="Hoffmeister, Michael" uniqKey="Hoffmeister M" first="Michael" last="Hoffmeister">Michael Hoffmeister</name><affiliation wicri:level="3"><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Houlston, Richard S" sort="Houlston, Richard S" uniqKey="Houlston R" first="Richard S" last="Houlston">Richard S. Houlston</name><affiliation wicri:level="1"><nlm:affiliation>Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Hung, Rayjean J" sort="Hung, Rayjean J" uniqKey="Hung R" first="Rayjean J" last="Hung">Rayjean J. Hung</name><affiliation wicri:level="1"><nlm:affiliation>Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Jenkins, Mark A" sort="Jenkins, Mark A" uniqKey="Jenkins M" first="Mark A" last="Jenkins">Mark A. Jenkins</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Harvard T.H Chan School of Public Health, Boston, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Epidemiology, Harvard T.H Chan School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Lawrenson, Kate" sort="Lawrenson, Kate" uniqKey="Lawrenson K" first="Kate" last="Lawrenson">Kate Lawrenson</name><affiliation wicri:level="2"><nlm:affiliation>Cedars-Sinai Medical Center, Los Angeles, CA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Cedars-Sinai Medical Center, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Mckay, James" sort="Mckay, James" uniqKey="Mckay J" first="James" last="Mckay">James Mckay</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Markt, Sarah" sort="Markt, Sarah" uniqKey="Markt S" first="Sarah" last="Markt">Sarah Markt</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Harvard T.H Chan School of Public Health, Boston, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Epidemiology, Harvard T.H Chan School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Mucci, Lorelei" sort="Mucci, Lorelei" uniqKey="Mucci L" first="Lorelei" last="Mucci">Lorelei Mucci</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Harvard T.H Chan School of Public Health, Boston, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Epidemiology, Harvard T.H Chan School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Phelan, Catherine M" sort="Phelan, Catherine M" uniqKey="Phelan C" first="Catherine M" last="Phelan">Catherine M. Phelan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cancer Epidemiology, Population Sciences Division, Moffitt Cancer Center, Tampa, FL.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Cancer Epidemiology, Population Sciences Division, Moffitt Cancer Center, Tampa</wicri:cityArea></affiliation></author><author><name sortKey="Qu, Conghui" sort="Qu, Conghui" uniqKey="Qu C" first="Conghui" last="Qu">Conghui Qu</name><affiliation wicri:level="2"><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Risch, Angela" sort="Risch, Angela" uniqKey="Risch A" first="Angela" last="Risch">Angela Risch</name><affiliation wicri:level="1"><nlm:affiliation>Division of Molecular Biology, University of Salzburg, Salzburg, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Molecular Biology, University of Salzburg, Salzburg</wicri:regionArea><wicri:noRegion>Salzburg</wicri:noRegion></affiliation></author><author><name sortKey="Rossing, Mary Anne" sort="Rossing, Mary Anne" uniqKey="Rossing M" first="Mary Anne" last="Rossing">Mary Anne Rossing</name><affiliation wicri:level="2"><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H-Erich" last="Wichmann">H-Erich Wichmann</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Medical Informatics, Biometry and Epidemiology, University of Munich, Munich, Bavaria, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Informatics, Biometry and Epidemiology, University of Munich, Munich, Bavaria</wicri:regionArea><wicri:noRegion>Bavaria</wicri:noRegion><orgName type="university">Université Louis-et-Maximilien de Munich</orgName><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName></affiliation></author><author><name sortKey="Shi, Jianxin" sort="Shi, Jianxin" uniqKey="Shi J" first="Jianxin" last="Shi">Jianxin Shi</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Schernhammer, Eva" sort="Schernhammer, Eva" uniqKey="Schernhammer E" first="Eva" last="Schernhammer">Eva Schernhammer</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Harvard T.H Chan School of Public Health, Boston, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Epidemiology, Harvard T.H Chan School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Yu, Kai" sort="Yu, Kai" uniqKey="Yu K" first="Kai" last="Yu">Kai Yu</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Landi, Maria Teresa" sort="Landi, Maria Teresa" uniqKey="Landi M" first="Maria Teresa" last="Landi">Maria Teresa Landi</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Caporaso, Neil E" sort="Caporaso, Neil E" uniqKey="Caporaso N" first="Neil E" last="Caporaso">Neil E. Caporaso</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28699174</idno><idno type="pmid">28699174</idno><idno type="doi">10.1002/ijc.30883</idno><idno type="wicri:Area/PubMed/Corpus">000104</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000104</idno><idno type="wicri:Area/PubMed/Curation">000104</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000104</idno><idno type="wicri:Area/PubMed/Checkpoint">000104</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000104</idno><idno type="wicri:Area/Ncbi/Merge">004B09</idno><idno type="wicri:Area/Ncbi/Curation">004B09</idno><idno type="wicri:Area/Ncbi/Checkpoint">004B09</idno><idno type="wicri:Area/Main/Merge">000974</idno><idno type="wicri:Area/Main/Curation">000979</idno><idno type="wicri:Area/Main/Exploration">000979</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Inherited variation in circadian rhythm genes and risks of prostate cancer and three other cancer sites in combined cancer consortia.</title><author><name sortKey="Gu, Fangyi" sort="Gu, Fangyi" uniqKey="Gu F" first="Fangyi" last="Gu">Fangyi Gu</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Zhang, Han" sort="Zhang, Han" uniqKey="Zhang H" first="Han" last="Zhang">Han Zhang</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Hyland, Paula L" sort="Hyland, Paula L" uniqKey="Hyland P" first="Paula L" last="Hyland">Paula L. Hyland</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Berndt, Sonja" sort="Berndt, Sonja" uniqKey="Berndt S" first="Sonja" last="Berndt">Sonja Berndt</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Gapstur, Susan M" sort="Gapstur, Susan M" uniqKey="Gapstur S" first="Susan M" last="Gapstur">Susan M. Gapstur</name><affiliation wicri:level="2"><nlm:affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, GA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Epidemiology Research Program, American Cancer Society, Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Wheeler, William" sort="Wheeler, William" uniqKey="Wheeler W" first="William" last="Wheeler">William Wheeler</name><affiliation wicri:level="2"><nlm:affiliation>Information Management Services, Inc, Rockville, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Information Management Services, Inc, Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Ellipse Consortium, The" sort="Ellipse Consortium, The" uniqKey="Ellipse Consortium T" first="The" last="Ellipse Consortium">The Ellipse Consortium</name></author><author><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I" last="Amos">Christopher I. Amos</name><affiliation wicri:level="2"><nlm:affiliation>Geisel School of Medicine at Dartmouth, Lebanon, NH.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Hampshire</region></placeName><wicri:cityArea>Geisel School of Medicine at Dartmouth, Lebanon</wicri:cityArea></affiliation></author><author><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stephane" last="Bezieau">Stephane Bezieau</name><affiliation wicri:level="3"><nlm:affiliation>Service de Génétique Médicale, CHU Nantes, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Génétique Médicale, CHU Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Bickeboller, Heike" sort="Bickeboller, Heike" uniqKey="Bickeboller H" first="Heike" last="Bickeböller">Heike Bickeböller</name><affiliation wicri:level="3"><nlm:affiliation>Department of Genetic Epidemiology, University Medical Center Göttingen, Göttingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genetic Epidemiology, University Medical Center Göttingen, Göttingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="3"><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation wicri:level="3"><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Conti, David V" sort="Conti, David V" uniqKey="Conti D" first="David V" last="Conti">David V. Conti</name><affiliation wicri:level="2"><nlm:affiliation>Keck School of Medicine, University of South California, Los Angeles, CA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Keck School of Medicine, University of South California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Doherty, Jennifer Anne" sort="Doherty, Jennifer Anne" uniqKey="Doherty J" first="Jennifer Anne" last="Doherty">Jennifer Anne Doherty</name><affiliation wicri:level="2"><nlm:affiliation>Huntsman Cancer Institute, University of Utah, Salt Lake City, UT.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Utah</region></placeName><wicri:cityArea>Huntsman Cancer Institute, University of Utah, Salt Lake City</wicri:cityArea></affiliation></author><author><name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B" last="Gruber">Stephen B. Gruber</name><affiliation wicri:level="2"><nlm:affiliation>Keck School of Medicine, University of South California, Los Angeles, CA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Keck School of Medicine, University of South California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Harrison, Tabitha A" sort="Harrison, Tabitha A" uniqKey="Harrison T" first="Tabitha A" last="Harrison">Tabitha A. Harrison</name><affiliation wicri:level="2"><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Hayes, Richard B" sort="Hayes, Richard B" uniqKey="Hayes R" first="Richard B" last="Hayes">Richard B. Hayes</name><affiliation wicri:level="2"><nlm:affiliation>Department of Population Health, New York University School of Medicine, New York, NY.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Population Health, New York University School of Medicine, New York</wicri:cityArea></affiliation></author><author><name sortKey="Hoffmeister, Michael" sort="Hoffmeister, Michael" uniqKey="Hoffmeister M" first="Michael" last="Hoffmeister">Michael Hoffmeister</name><affiliation wicri:level="3"><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Houlston, Richard S" sort="Houlston, Richard S" uniqKey="Houlston R" first="Richard S" last="Houlston">Richard S. Houlston</name><affiliation wicri:level="1"><nlm:affiliation>Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Hung, Rayjean J" sort="Hung, Rayjean J" uniqKey="Hung R" first="Rayjean J" last="Hung">Rayjean J. Hung</name><affiliation wicri:level="1"><nlm:affiliation>Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Jenkins, Mark A" sort="Jenkins, Mark A" uniqKey="Jenkins M" first="Mark A" last="Jenkins">Mark A. Jenkins</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Harvard T.H Chan School of Public Health, Boston, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Epidemiology, Harvard T.H Chan School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Lawrenson, Kate" sort="Lawrenson, Kate" uniqKey="Lawrenson K" first="Kate" last="Lawrenson">Kate Lawrenson</name><affiliation wicri:level="2"><nlm:affiliation>Cedars-Sinai Medical Center, Los Angeles, CA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Cedars-Sinai Medical Center, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Mckay, James" sort="Mckay, James" uniqKey="Mckay J" first="James" last="Mckay">James Mckay</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Markt, Sarah" sort="Markt, Sarah" uniqKey="Markt S" first="Sarah" last="Markt">Sarah Markt</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Harvard T.H Chan School of Public Health, Boston, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Epidemiology, Harvard T.H Chan School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Mucci, Lorelei" sort="Mucci, Lorelei" uniqKey="Mucci L" first="Lorelei" last="Mucci">Lorelei Mucci</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Harvard T.H Chan School of Public Health, Boston, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Epidemiology, Harvard T.H Chan School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Phelan, Catherine M" sort="Phelan, Catherine M" uniqKey="Phelan C" first="Catherine M" last="Phelan">Catherine M. Phelan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cancer Epidemiology, Population Sciences Division, Moffitt Cancer Center, Tampa, FL.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Cancer Epidemiology, Population Sciences Division, Moffitt Cancer Center, Tampa</wicri:cityArea></affiliation></author><author><name sortKey="Qu, Conghui" sort="Qu, Conghui" uniqKey="Qu C" first="Conghui" last="Qu">Conghui Qu</name><affiliation wicri:level="2"><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Risch, Angela" sort="Risch, Angela" uniqKey="Risch A" first="Angela" last="Risch">Angela Risch</name><affiliation wicri:level="1"><nlm:affiliation>Division of Molecular Biology, University of Salzburg, Salzburg, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Molecular Biology, University of Salzburg, Salzburg</wicri:regionArea><wicri:noRegion>Salzburg</wicri:noRegion></affiliation></author><author><name sortKey="Rossing, Mary Anne" sort="Rossing, Mary Anne" uniqKey="Rossing M" first="Mary Anne" last="Rossing">Mary Anne Rossing</name><affiliation wicri:level="2"><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H-Erich" last="Wichmann">H-Erich Wichmann</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Medical Informatics, Biometry and Epidemiology, University of Munich, Munich, Bavaria, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Informatics, Biometry and Epidemiology, University of Munich, Munich, Bavaria</wicri:regionArea><wicri:noRegion>Bavaria</wicri:noRegion><orgName type="university">Université Louis-et-Maximilien de Munich</orgName><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName></affiliation></author><author><name sortKey="Shi, Jianxin" sort="Shi, Jianxin" uniqKey="Shi J" first="Jianxin" last="Shi">Jianxin Shi</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Schernhammer, Eva" sort="Schernhammer, Eva" uniqKey="Schernhammer E" first="Eva" last="Schernhammer">Eva Schernhammer</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Harvard T.H Chan School of Public Health, Boston, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Epidemiology, Harvard T.H Chan School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Yu, Kai" sort="Yu, Kai" uniqKey="Yu K" first="Kai" last="Yu">Kai Yu</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Landi, Maria Teresa" sort="Landi, Maria Teresa" uniqKey="Landi M" first="Maria Teresa" last="Landi">Maria Teresa Landi</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Caporaso, Neil E" sort="Caporaso, Neil E" uniqKey="Caporaso N" first="Neil E" last="Caporaso">Neil E. Caporaso</name><affiliation wicri:level="2"><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville</wicri:cityArea></affiliation></author></analytic><series><title level="j">International journal of cancer</title><idno type="eISSN">1097-0215</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arylalkylamine N-Acetyltransferase (genetics)</term><term>Basic Helix-Loop-Helix Transcription Factors (genetics)</term><term>Carcinogenesis (genetics)</term><term>Circadian Rhythm (genetics)</term><term>Colorectal Neoplasms (genetics)</term><term>Colorectal Neoplasms (pathology)</term><term>Female</term><term>Genetic Association Studies</term><term>Genetic Predisposition to Disease</term><term>Humans</term><term>Lung Neoplasms (genetics)</term><term>Lung Neoplasms (pathology)</term><term>Male</term><term>Nerve Tissue Proteins (genetics)</term><term>Ovarian Neoplasms (genetics)</term><term>Ovarian Neoplasms (pathology)</term><term>Polymorphism, Single Nucleotide</term><term>Prostatic Neoplasms (genetics)</term><term>Prostatic Neoplasms (pathology)</term><term>Signal Transduction (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Arylalkylamine N-Acetyltransferase (génétique)</term><term>Carcinogenèse (génétique)</term><term>Facteurs de transcription à motif basique hélice-boucle-hélice (génétique)</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Polymorphisme de nucléotide simple</term><term>Protéines de tissu nerveux (génétique)</term><term>Prédisposition génétique à une maladie</term><term>Rythme circadien (génétique)</term><term>Transduction du signal (génétique)</term><term>Tumeurs colorectales (anatomopathologie)</term><term>Tumeurs colorectales (génétique)</term><term>Tumeurs de l'ovaire (anatomopathologie)</term><term>Tumeurs de l'ovaire (génétique)</term><term>Tumeurs de la prostate (anatomopathologie)</term><term>Tumeurs de la prostate (génétique)</term><term>Tumeurs du poumon (anatomopathologie)</term><term>Tumeurs du poumon (génétique)</term><term>Études d'associations génétiques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Arylalkylamine N-Acetyltransferase</term><term>Basic Helix-Loop-Helix Transcription Factors</term><term>Nerve Tissue Proteins</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs colorectales</term><term>Tumeurs de l'ovaire</term><term>Tumeurs de la prostate</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Carcinogenesis</term><term>Circadian Rhythm</term><term>Colorectal Neoplasms</term><term>Lung Neoplasms</term><term>Ovarian Neoplasms</term><term>Prostatic Neoplasms</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Arylalkylamine N-Acetyltransferase</term><term>Carcinogenèse</term><term>Facteurs de transcription à motif basique hélice-boucle-hélice</term><term>Protéines de tissu nerveux</term><term>Rythme circadien</term><term>Transduction du signal</term><term>Tumeurs colorectales</term><term>Tumeurs de l'ovaire</term><term>Tumeurs de la prostate</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Colorectal Neoplasms</term><term>Lung Neoplasms</term><term>Ovarian Neoplasms</term><term>Prostatic Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Genetic Association Studies</term><term>Genetic Predisposition to Disease</term><term>Humans</term><term>Male</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Polymorphisme de nucléotide simple</term><term>Prédisposition génétique à une maladie</term><term>Études d'associations génétiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Circadian disruption has been linked to carcinogenesis in animal models, but the evidence in humans is inconclusive. Genetic variation in circadian rhythm genes provides a tool to investigate such associations. We examined associations of genetic variation in nine core circadian rhythm genes and six melatonin pathway genes with risk of colorectal, lung, ovarian and prostate cancers using data from the Genetic Associations and Mechanisms in Oncology (GAME-ON) network. The major results for prostate cancer were replicated in the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial, and for colorectal cancer in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO). The total number of cancer cases and controls was 15,838/18,159 for colorectal, 14,818/14,227 for prostate, 12,537/17,285 for lung and 4,369/9,123 for ovary. For each cancer site, we conducted gene-based and pathway-based analyses by applying the summary-based Adaptive Rank Truncated Product method (sARTP) on the summary association statistics for each SNP within the candidate gene regions. Aggregate genetic variation in circadian rhythm and melatonin pathways were significantly associated with the risk of prostate cancer in data combining GAME-ON and PLCO, after Bonferroni correction (ppathway < 0.00625). The two most significant genes were NPAS2 (pgene = 0.0062) and AANAT (pgene = 0.00078); the latter being significant after Bonferroni correction. For colorectal cancer, we observed a suggestive association with the circadian rhythm pathway in GAME-ON (ppathway = 0.021); this association was not confirmed in GECCO (ppathway = 0.76) or the combined data (ppathway = 0.17). No significant association was observed for ovarian and lung cancer. These findings support a potential role for circadian rhythm and melatonin pathways in prostate carcinogenesis. Further functional studies are needed to better understand the underlying biologic mechanisms.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Canada</li><li>France</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Bade-Wurtemberg</li><li>Basse-Saxe</li><li>Bavière</li><li>Californie</li><li>District de Haute-Bavière</li><li>District de Karlsruhe</li><li>Floride</li><li>Géorgie (États-Unis)</li><li>Maryland</li><li>Massachusetts</li><li>New Hampshire</li><li>Pays de la Loire</li><li>Rhône-Alpes</li><li>Utah</li><li>Victoria (État)</li><li>Washington (État)</li><li>État de New York</li></region><settlement><li>Göttingen</li><li>Heidelberg</li><li>Lyon</li><li>Melbourne</li><li>Munich</li><li>Nantes</li></settlement><orgName><li>Université Louis-et-Maximilien de Munich</li><li>Université de Melbourne</li></orgName></list><tree><noCountry><name sortKey="Ellipse Consortium, The" sort="Ellipse Consortium, The" uniqKey="Ellipse Consortium T" first="The" last="Ellipse Consortium">The Ellipse Consortium</name></noCountry><country name="États-Unis"><region name="Maryland"><name sortKey="Gu, Fangyi" sort="Gu, Fangyi" uniqKey="Gu F" first="Fangyi" last="Gu">Fangyi Gu</name></region><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I" last="Amos">Christopher I. Amos</name><name sortKey="Berndt, Sonja" sort="Berndt, Sonja" uniqKey="Berndt S" first="Sonja" last="Berndt">Sonja Berndt</name><name sortKey="Caporaso, Neil E" sort="Caporaso, Neil E" uniqKey="Caporaso N" first="Neil E" last="Caporaso">Neil E. Caporaso</name><name sortKey="Conti, David V" sort="Conti, David V" uniqKey="Conti D" first="David V" last="Conti">David V. Conti</name><name sortKey="Doherty, Jennifer Anne" sort="Doherty, Jennifer Anne" uniqKey="Doherty J" first="Jennifer Anne" last="Doherty">Jennifer Anne Doherty</name><name sortKey="Gapstur, Susan M" sort="Gapstur, Susan M" uniqKey="Gapstur S" first="Susan M" last="Gapstur">Susan M. Gapstur</name><name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B" last="Gruber">Stephen B. Gruber</name><name sortKey="Harrison, Tabitha A" sort="Harrison, Tabitha A" uniqKey="Harrison T" first="Tabitha A" last="Harrison">Tabitha A. Harrison</name><name sortKey="Hayes, Richard B" sort="Hayes, Richard B" uniqKey="Hayes R" first="Richard B" last="Hayes">Richard B. Hayes</name><name sortKey="Hyland, Paula L" sort="Hyland, Paula L" uniqKey="Hyland P" first="Paula L" last="Hyland">Paula L. Hyland</name><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><name sortKey="Landi, Maria Teresa" sort="Landi, Maria Teresa" uniqKey="Landi M" first="Maria Teresa" last="Landi">Maria Teresa Landi</name><name sortKey="Lawrenson, Kate" sort="Lawrenson, Kate" uniqKey="Lawrenson K" first="Kate" last="Lawrenson">Kate Lawrenson</name><name sortKey="Markt, Sarah" sort="Markt, Sarah" uniqKey="Markt S" first="Sarah" last="Markt">Sarah Markt</name><name sortKey="Mucci, Lorelei" sort="Mucci, Lorelei" uniqKey="Mucci L" first="Lorelei" last="Mucci">Lorelei Mucci</name><name sortKey="Phelan, Catherine M" sort="Phelan, Catherine M" uniqKey="Phelan C" first="Catherine M" last="Phelan">Catherine M. Phelan</name><name sortKey="Qu, Conghui" sort="Qu, Conghui" uniqKey="Qu C" first="Conghui" last="Qu">Conghui Qu</name><name sortKey="Rossing, Mary Anne" sort="Rossing, Mary Anne" uniqKey="Rossing M" first="Mary Anne" last="Rossing">Mary Anne Rossing</name><name sortKey="Schernhammer, Eva" sort="Schernhammer, Eva" uniqKey="Schernhammer E" first="Eva" last="Schernhammer">Eva Schernhammer</name><name sortKey="Shi, Jianxin" sort="Shi, Jianxin" uniqKey="Shi J" first="Jianxin" last="Shi">Jianxin Shi</name><name sortKey="Wheeler, William" sort="Wheeler, William" uniqKey="Wheeler W" first="William" last="Wheeler">William Wheeler</name><name sortKey="Yu, Kai" sort="Yu, Kai" uniqKey="Yu K" first="Kai" last="Yu">Kai Yu</name><name sortKey="Zhang, Han" sort="Zhang, Han" uniqKey="Zhang H" first="Han" last="Zhang">Han Zhang</name></country><country name="France"><region name="Pays de la Loire"><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stephane" last="Bezieau">Stephane Bezieau</name></region><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><name sortKey="Mckay, James" sort="Mckay, James" uniqKey="Mckay J" first="James" last="Mckay">James Mckay</name></country><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Bickeboller, Heike" sort="Bickeboller, Heike" uniqKey="Bickeboller H" first="Heike" last="Bickeböller">Heike Bickeböller</name></region><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><name sortKey="Hoffmeister, Michael" sort="Hoffmeister, Michael" uniqKey="Hoffmeister M" first="Michael" last="Hoffmeister">Michael Hoffmeister</name><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H-Erich" last="Wichmann">H-Erich Wichmann</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Houlston, Richard S" sort="Houlston, Richard S" uniqKey="Houlston R" first="Richard S" last="Houlston">Richard S. Houlston</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Hung, Rayjean J" sort="Hung, Rayjean J" uniqKey="Hung R" first="Rayjean J" last="Hung">Rayjean J. Hung</name></noRegion></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Jenkins, Mark A" sort="Jenkins, Mark A" uniqKey="Jenkins M" first="Mark A" last="Jenkins">Mark A. Jenkins</name></region></country><country name="Autriche"><noRegion><name sortKey="Risch, Angela" sort="Risch, Angela" uniqKey="Risch A" first="Angela" last="Risch">Angela Risch</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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